Stem Cells in the News

1.Crane GM, Jeffery E, Morrison SJ. Adult haematopoietic stem cell niches. Nat Rev Immunol. 2017;17:573–90.CAS  PubMed  Article  PubMed Central  Google Scholar  2.Spencer JA, Ferraro F, Roussakis E, Klein A, Wu J, Runnels JM, et al. Direct measurement of local oxygen concentration in the bone marrow of live animals. Nature. 2014;508:269–73.CAS  PubMed  PubMed Central  Article  Google [...] Published September 12, 2021 at 07:25PM. Read full article at Stem Cells in the News Portal .

1.Mehrabi S, Eftekhari S, Moradi F, Delaviz H, Pourheidar B, Azizi M, et al. Cell therapy in spinal cord injury: a mini-reivew. Basic Clin Neurosci. 2013;4:172–6.PubMed  PubMed Central  Google Scholar  2.Anna Z, Katarzyna J-W, Joanna C, Barczewska M, Joanna W, Wojciech M. Therapeutic potential of olfactory ensheathing cells and mesenchymal stem cells in spinal cord [...] Published September 08, 2021 at 07:20PM. Read full article at Stem Cells in the News Portal .

MiceAnimal experiments were performed with adult 6- to 16-week-old mice with equal numbers of males and females. All mice were provided sterile pellet food and water ad libitum. C57BL/6N mice were purchased from Orient Bio (South Korea), and Gpr81−/− mice were generated as described previously23. CD45.1+ (B6. SJL-Ptprca Pepcb/BoyJ), LepR-cre (B6.129(Cg)- LepRtm2(cre)Rck/J), and tdTomato-loxP (B6. [...] Published September 08, 2021 at 07:19PM. Read full article at Stem Cells in the News Portal .

1.WHO. Coronavirus disease (COVID-2019) situation reports, https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports (2020).2.Gupta, A. et al. Extrapulmonary manifestations of COVID-19. Nat. Med. 26, 1017–1032 (2020).CAS  PubMed  Article  Google Scholar  3.Petersen, E. et al. Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics. Lancet Infect. Dis. 20, e238–e244 (2020).CAS  PubMed  PubMed Central  Article  Google Scholar  4.Richardson, S. et al. Presenting Characteristics, Comorbidities, and [...] Published September 07, 2021 at 07:01PM. Read full article at Stem Cells in the News Portal .

Activation-induced DHX36 is required for muscle formationTo dissect whether DHX36 functions in SCs and muscle regeneration, we first examined Dhx36 expression dynamics during SC myogenic progression. Quiescent SCs were isolated by fluorescence-activated cell sorting (FACS) from Pax7-nGFP mice25, either fixed in situ by 0.5% paraformaldehyde (PFA) prior to muscle digestion (SCT0) or from muscles digested [...] Published August 18, 2021 at 07:58PM. Read full article at Stem Cells in the News Portal .

Detailed formulae to estimate direct adjusted survival functions and their variances are published [6]. Constructing confidence bands and computing simultaneous p values is described by Wang and Zhang [8]. For left-truncated data,the risk-set needs to be appropriately adjusted at estimating time individually.Improvements in computational performance%adjsurvlt() has several computational enhancements. First, instead of repeating large blocks [...] Published August 18, 2021 at 07:39PM. Read full article at Stem Cells in the News Portal .

1.Cable J, Fuchs E, Weissman I, Jasper H, Glass D, Rando T, et al. Adult stem cells and regenerative medicine—a symposium report. Ann. N. Y. Acad. Sci. 2020;1462:27.PubMed  Article  Google Scholar  2.Yamanaka S. Pluripotent stem cell-based cell therapy-promise and challenges. Cell Stem Cell. 2020;27:523–31.CAS  PubMed  Article  Google Scholar  3.Adam RC, Yang H, Rockowitz S, Larsen [...] Published August 15, 2021 at 07:46PM. Read full article at Stem Cells in the News Portal .

Ethics statementAll animal operations were in accordance with the operating standards of laboratory animals established by the animal ethics committee of the Xiangya Hospital of Central-South University. All efforts were made to minimize the animal suffering. Informed consent was signed by each umbilical cord donor.Isolation and identification of HucMSCsThe fresh umbilical cords were collected and [...] Published August 10, 2021 at 07:45PM. Read full article at Stem Cells in the News Portal .

1.Allen, K. A. & Brandon, D. H. Hypoxic ischemic encephalopathy: Pathophysiology and experimental treatments. Newborn Infant Nurs. Rev. 11(3), 125–133 (2011).PubMed  PubMed Central  Article  Google Scholar  2.Burnsed, J. C. et al. Hypoxia-ischemia and therapeutic hypothermia in the neonatal mouse brain: A longitudinal study. PLoS ONE 10(3), e0118889 (2015).PubMed  PubMed Central  Article  CAS  Google Scholar  3.Edwards, [...] Published August 03, 2021 at 07:17PM. Read full article at Stem Cells in the News Portal .

1.Eskelund CW, Kolstad A, Jerkeman M, Räty R, Laurell A, Eloranta S, et al. 15-year follow-up of the Second Nordic Mantle Cell Lymphoma trial (MCL2): prolonged remissions without survival plateau. Br J Haematol. 2016;175:410–8.CAS  Article  Google Scholar  2.Eskelund CW, Dahl C, Hansen JW, Westman M, Kolstad A, Pedersen LB, et al. TP53 mutations identify younger [...] Published July 19, 2021 at 07:44PM. Read full article at Stem Cells in the News Portal .

1.Schuurhuis GJ, Heuser M, Freeman S, Béné MC, Buccisano F, Cloos J, et al. Minimal/measurable residual disease in AML: a consensus document from the European LeukemiaNet MRD Working Party. Blood 2018;131:1275–91.CAS  Article  Google Scholar  2.Dillon R, Potter N, Freeman S, Russell N. How we use molecular minimal residual disease (MRD) testing in acute myeloid leukaemia [...] Published July 15, 2021 at 07:16PM. Read full article at Stem Cells in the News Portal .

1.Zhao, C., Deng, W. & Gage, F. H. Mechanisms and functional implications of adult neurogenesis. Cell 132, 645–660 (2008).CAS  PubMed  Article  PubMed Central  Google Scholar  2.Ming, G.-L. & Song, H. Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron 70, 687–702 (2011).CAS  PubMed  PubMed Central  Article  Google Scholar  3.Lim, D. A. & [...] Published July 14, 2021 at 07:13PM. Read full article at Stem Cells in the News Portal .

GPX4 deficiency results in HSPCs ferroptosis in vitroHSCs rapidly proliferate and differentiate to generate single-cell colonies when they are cultured in vitro. For determination of whether GPX4 is essential for HSC function, individual long-term HSCs (LT-HSCs) from wild-type mice were sorted and treated with RSL3, a widely used GPX4 inhibitor. Strikingly, RSL3 completely blocked the [...] Published July 14, 2021 at 07:56PM. Read full article at Stem Cells in the News Portal .

1.Gregory, J. M., Cherrington, A. D. & Moore, D. J. Diabetes 69, 837–847 (2020).CAS  Article  Google Scholar  2.Heller, S. Diabetes Res. Clin. Pract. 65 (Suppl. 1), S23–S27 (2004).3.Warnock, G. L. et al. Transplantation 86, 1762–1766 (2008).Article  Google Scholar  4.Gamble, A., Pepper, A. R., Bruni, A. & Shapiro, A. M. J. Islets 10, 80–94 (2018).Article  Google [...] Published July 11, 2021 at 08:00PM. Read full article at Stem Cells in the News Portal .

1.Tamari R, Castro-Malaspina H. Transplant for MDS: challenges and emerging strategies. Best Pract Res Clin Haematol. 2015;28:43–54.Article  Google Scholar  2.D’Souza A, Lee S, Zhu X, Pasquini M. Current use of and trends in hematopoietic cell transplantation in the United States. Biol Blood Marrow Transplant. 2017;23:1417–21.Article  Google Scholar  3.Tamari R, Chung SS, Papadopoulos EB, Jakubowski AA, [...] Published July 11, 2021 at 07:21PM. Read full article at Stem Cells in the News Portal .

Mantle cell lymphoma (MCL) is a rare disease with an aggressive clinical course in most patients. This resulted in a median survival of MCL of only 3–5 years [1]. Intensive first-line chemo-immunotherapy with autograft has improved the clinical outcome of MCL. However, the clinical course remains heterogeneous and can only be partially predicted with internationally [...] Published July 06, 2021 at 07:38PM. Read full article at Stem Cells in the News Portal .

In a study recently published in Nature, Shen and colleagues characterized a peri-arteriolar niche in the bone marrow with highly proliferative, short-lived, leptin receptor- and osteolectin (Oln) positive stromal cells, which improved bone regeneration and supported bacterial clearance after fracture. By proving that maintenance of these cells critically required mechanical stimulation, which in turn was [...] Published July 06, 2021 at 07:08PM. Read full article at Stem Cells in the News Portal .

‘We are human because we recount stories and myths…’ Herodotus (The Histories).Greek historian. 484–425 B C.As far as I can remember news and events presented by the media (print and television) were rather dry and factual until recently. Now ‘news’ is presented as stories and newscasters/presenters have become celebrities, like oenologists/wine consultants or chefs, among [...] Published July 05, 2021 at 07:06PM. Read full article at Stem Cells in the News Portal .

Cell cultureThe mouse ESCs were purchased from National Cell Resource Center (Shanghai, China) and cultured in Knockout Dulbecco’s modified Eagle’s medium (DMEM) supplemented with 15% knockout Serum Replacement, 2 nM l-glutamine, 50 units/ml penicillin, 50 μg/ml streptomycin, 1% minimal essential medium nonessential amino acids, and β-mercaptoethanol, which are purchased from Thermo-Fisher and Sigma Company. The ESCs were cultured [...] Published July 01, 2021 at 07:08PM. Read full article at Stem Cells in the News Portal .

1.Bajaj, J., Diaz, E. & Reya, T. Stem cells in cancer initiation and progression. J Cell Biol. https://doi.org/10.1083/jcb.201911053 (2020).2.Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J. & Clarke, M. F. Prospective identification of tumorigenic breast cancer cells. Proc. Natl Acad. Sci. USA 100, 3983–3988 (2003).CAS  PubMed  PubMed Central  Article  Google Scholar  3.Driessens, G., [...] Published June 23, 2021 at 07:05PM. Read full article at Stem Cells in the News Portal .