Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells

MiceAnimal experiments were performed with adult 6- to 16-week-old mice with equal numbers of males and females. All mice were provided sterile pellet food and water ad libitum. C57BL/6N mice were purchased from Orient Bio (South Korea), and Gpr81−/− mice were generated as described previously23. CD45.1+ (B6. SJL-Ptprca Pepcb/BoyJ), LepR-cre (B6.129(Cg)- LepRtm2(cre)Rck/J), and tdTomato-loxP (B6. [...]

Published September 08, 2021 at 07:19PM. Read full article at Stem Cells in the News Portal.