Stem Cells in the News

Are prematurely aged or overworked stem cells a significant factor in chronic lung disease? Findings of a study just released in STEM CELLS Translational Medicine (SCTM) say this is likely so. The study determined that repeated injury to the epithelial tissue of the airways causes “biological aging” of the stem cells located there. “This premature aging of [...] Published September 21, 2021 at 08:15AM. Read full article at Stem Cells in the News Portal .

Bone injuries in the face and skull -- known as craniomaxillofacial defects -- can be caused by sports injuries, vehicle accidents, or battlefield injuries. Repairing such defects is complicated because different types of cells need to interact with each other. In a new study, researchers are investigating the types of material used in reconstruction to [...] Published September 13, 2021 at 09:44PM. Read full article at Stem Cells in the News Portal .

A study released in STEM CELLS Translational Medicine (SCTM), by researchers at the Baker Institute for Animal Health, part of Cornell University’s College of Veterinary Medicine, Ithaca, N.Y., details in a relevant ex vivo model how treating wounds with the secretion of a type of stem cell called mesenchymal stromal cell (MSC) effectively reduced methicillin-resistant Staphylococcus aureus – better known [...] Published September 16, 2021 at 08:35AM. Read full article at Stem Cells in the News Portal .

As we age, our bones become thinner, we suffer fractures more often, and bone-diseases such as osteoporosis are more likely to occur. One responsible mechanism involves the impaired function of the bone-marrow stem cells, which are required for the maintenance of bone integrity. Researchers from the Max Planck Institute for Biology of Ageing and CECAD [...] Published September 14, 2021 at 12:37PM. Read full article at Stem Cells in the News Portal .

A University at Buffalo-led research team has shown that a protein named for the mythical land of youth in Irish folklore is effective at reversing aging in skeletal muscle cells. Published Sept. 3 in Science Advances, the study centers on the protein NANOG, which is derived from Tír na nÓg, a place in Irish lore [...] Published September 14, 2021 at 06:13PM. Read full article at Stem Cells in the News Portal .

An immunological molecule called fractalkine can boost the production of brain cells that produce myelin, a key factor in diseases such as multiple sclerosis, according to recent research from the University of Alberta. Myelin is an insulating layer around nerves that is gradually worn away by inflammation in multiple sclerosis and similar diseases. Without this [...] Published September 09, 2021 at 01:26PM. Read full article at Stem Cells in the News Portal .

For species that rely on sexual reproduction, including mice and men, offspring can only happen if sperm from the male fertilize eggs from the female. Even artificial fertilization techniques depend on donors for both of these cells. However, a new study led by ASHBi researchers shows that mouse pluripotent stem cells can differentiate into functional [...] Published September 07, 2021 at 10:51AM. Read full article at Stem Cells in the News Portal .

1.Crane GM, Jeffery E, Morrison SJ. Adult haematopoietic stem cell niches. Nat Rev Immunol. 2017;17:573–90.CAS  PubMed  Article  PubMed Central  Google Scholar  2.Spencer JA, Ferraro F, Roussakis E, Klein A, Wu J, Runnels JM, et al. Direct measurement of local oxygen concentration in the bone marrow of live animals. Nature. 2014;508:269–73.CAS  PubMed  PubMed Central  Article  Google [...] Published September 12, 2021 at 07:25PM. Read full article at Stem Cells in the News Portal .

Mouse embryonic stem cells undergoing electrochemical specialization, labeled for nuclei (blue) and neuron projections (red). Credit: © Mitchell Foster and Adele Doyle New TU Dresden research group aims to uncover how stem cells respond to mechanical forces and electrical cues during the development and maintenance of the nervous and cardiovascular system. Dr. Adele Doyle, Assistant [...] Published September 12, 2021 at 06:09AM. Read full article at Stem Cells in the News Portal .

1.Mehrabi S, Eftekhari S, Moradi F, Delaviz H, Pourheidar B, Azizi M, et al. Cell therapy in spinal cord injury: a mini-reivew. Basic Clin Neurosci. 2013;4:172–6.PubMed  PubMed Central  Google Scholar  2.Anna Z, Katarzyna J-W, Joanna C, Barczewska M, Joanna W, Wojciech M. Therapeutic potential of olfactory ensheathing cells and mesenchymal stem cells in spinal cord [...] Published September 08, 2021 at 07:20PM. Read full article at Stem Cells in the News Portal .

MiceAnimal experiments were performed with adult 6- to 16-week-old mice with equal numbers of males and females. All mice were provided sterile pellet food and water ad libitum. C57BL/6N mice were purchased from Orient Bio (South Korea), and Gpr81−/− mice were generated as described previously23. CD45.1+ (B6. SJL-Ptprca Pepcb/BoyJ), LepR-cre (B6.129(Cg)- LepRtm2(cre)Rck/J), and tdTomato-loxP (B6. [...] Published September 08, 2021 at 07:19PM. Read full article at Stem Cells in the News Portal .

Illinois researchers developed a method that makes membrane-bound receptors reactive to light, triggering the Wnt pathway, important in embryonic development and cancer. Credit: Image courtesy of Kai Zhang Blue light is illuminating new understanding of a key signaling pathway in embryo development, tissue maintenance, and cancer genesis. Researchers at the University of Illinois Urbana-Champaign developed [...] Published September 08, 2021 at 12:02PM. Read full article at Stem Cells in the News Portal .

1.WHO. Coronavirus disease (COVID-2019) situation reports, https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports (2020).2.Gupta, A. et al. Extrapulmonary manifestations of COVID-19. Nat. Med. 26, 1017–1032 (2020).CAS  PubMed  Article  Google Scholar  3.Petersen, E. et al. Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics. Lancet Infect. Dis. 20, e238–e244 (2020).CAS  PubMed  PubMed Central  Article  Google Scholar  4.Richardson, S. et al. Presenting Characteristics, Comorbidities, and [...] Published September 07, 2021 at 07:01PM. Read full article at Stem Cells in the News Portal .

A convection-enhanced encapsulation device as pictured enhances nutrient transport leading to improved survival and improved glucose responsive insulin secretion of the transplanted beta cells. Credit: Randal McKenzie Brigham bioengineers have developed a convection-enhanced macroencapsulation device that offers the potential of faster and more effective treatment for people with type 1 diabetes. More than 40 million [...] Published September 06, 2021 at 02:38PM. Read full article at Stem Cells in the News Portal .

In a new study by Yale Cancer Center, researchers show stem-like T cells within certain lymph nodes could be natural cancer fighters. Targeting these T cells, which are a type of white blood cells, with immunotherapy drugs could increase the number of cancer patients that respond to treatment. The findings were reported online today in [...] Published September 03, 2021 at 09:39AM. Read full article at Stem Cells in the News Portal .

In the United States, as many as 187,000 people are coping with myelodysplastic syndromes (MDS) that damage the bone marrow's ability to produce healthy blood cells. In most cases, MDS is caused by mutations that arise in blood stem cells during a person's life. These patients experience anemia, fatigue, and other complications, with a typical [...] Published September 02, 2021 at 11:52AM. Read full article at Stem Cells in the News Portal .

A study led by researchers from Brigham and Women's Hospital has established a new resource for exploring and understanding Alzheimer's disease (AD) on an individualized level. The team generated induced pluripotent stem cell (iPSC) lines from over 50 different individuals for whom longitudinal clinical data, quantitative neuropathology data, and rich genetic and molecular profiling of [...] Published September 01, 2021 at 11:14AM. Read full article at Stem Cells in the News Portal .

McGill University researchers identify proteins that drive cancer stem cells. Targeting and supressing a particular protein called galectin1 could provide a more effective treatment for glioblastoma, in combination with radiation therapy. Due to its resistance to therapy, glioblastoma is the most common and aggressive cancerous brain tumour in adults. It grows fast and spreads quickly. [...] Published August 31, 2021 at 12:42PM. Read full article at Stem Cells in the News Portal .

The human body can be genetically inclined to attack its own cells, destroying the beta cells in the pancreas that make insulin, which helps convert sugar into energy. Called Type 1 diabetes, this disorder can occur at any age and can be fatal if not carefully managed with insulin shots or an insulin pump to [...] Published August 26, 2021 at 04:29PM. Read full article at Stem Cells in the News Portal .

Basal epithelial stem cells (green) containing the protein IL-33 (red) are visible in a sample of lung tissue (pictured). Researchers at Washington University School of Medicine in St. Louis have found that such stem cells multiply during and after a viral respiratory infection, sometimes triggering a detrimental remodeling process that can cause persistent lung disease [...] Published August 28, 2021 at 10:50AM. Read full article at Stem Cells in the News Portal .