Luspatercept restores SDF-1-mediated hematopoietic support by MDS-derived mesenchymal stromal cells

Luspatercept/RAP-536 modulates Smad2/3 signaling and Smad4 expression in MSCsStandardized conditions for the in vitro treatment of human MSCs with GDF-11 and the luspatercept homolog RAP-536 were established on the basis of Smad2/3 phosphorylation levels. Recombinant GDF-11 at a concentration of 0.1 µg/ml was found to induce Smad2/3 signaling in both healthy and MDS MSCs, while a [...]

Published May 16, 2021 at 07:49PM. Read full article at Stem Cells in the News Portal.