Doublecortin-Like Kinase 1 Promotes Hepatocyte Clonogenicity and Oncogenic Programming via Non-Canonical β-Catenin-Dependent Mechanism

DCLK1 induces spheroid growth of primary human hepatocytes in 3D suspension cultureWe previously demonstrated that normal human liver parenchyma stains negatively for DCLK1. However, when primary human hepatocytes from normal livers are cultured in Matrigel, which contains several growth factors and extracellular matrix, some cells form spheroids containing numerous DCLK1 + cells16. These spheroids upon further growth [...]

Published July 03, 2020 at 10:33PM. Read full article at Stem Cells in the News Portal.