Stem Cells in the News

Screening possible immune functions related to anticancer treatmentCommon immune checkpoints were browsed and screened for possible immunotherapeutic value, and the representative immune checkpoint molecules13,14,15 ADORA2A, BTLA, Nectin-2 (CD112), CD160, CD244, PD-L1, CD96, CSF1R, CTLA4, HAVCR2, IDO1, IL10, IL10RB, KDR, KIR2DL1, KIR2DL3, LAG3, LGALS9, PDCD1, PDCD1LG2, PVRL2, TGFB1, TGFBR1, TIGIT, VTCN1, TNF Receptor Superfamily Member 14 [...] Published September 20, 2021 at 02:42PM. Read full article at Stem Cells in the News Portal .

Dear Editor,Up to now, hematopoietic stem cells (HSCs) that contribute to all mature blood cell lineages in adults still cannot be efficiently regenerated in vitro, at least in part due to the insufficient understanding of their physiological developmental trajectories and the underlying precise regulatory mechanisms. In mouse embryos, the first HSCs are believed to be [...] Published September 20, 2021 at 09:39PM. Read full article at Stem Cells in the News Portal .

I’ve been busy recently focusing more on grant and paper writing than reading papers on stem cells, but my piece on trying to de-extinct mammoths via cloning-like methods drew strong opinions on both sides.Recent news and resources on stem cellsWe’re still awaiting a verdict in the big California federal court case where the FDA is seeking a [...] Published September 19, 2021 at 03:15PM. Read full article at Stem Cells in the News Portal .

Credit: ShutterstockLike a headline from the Onion, I recently read an email describing a big orthopedic surgery conference where a panel was sourced on whether or not you needed ultrasound guidance to inject a knee. While the result of this panel was a LOL moment for many of my colleagues, none of us really knew [...] Published September 18, 2021 at 02:55PM. Read full article at Stem Cells in the News Portal .

1.Chaffer, C. L. & Weinberg, R. A. A perspective on cancer cell metastasis. Science 331, 1559–1564 (2011).CAS  PubMed  Article  PubMed Central  Google Scholar  2.Tseng, P.-L. et al. The decrease of glycolytic enzyme hexokinase 1 accelerates tumor malignancy via deregulating energy metabolism but sensitizes cancer cells to 2-deoxyglucose inhibition. Oncotarget 9, 18949–18969 (2018).PubMed  PubMed Central  Article  [...] Published September 17, 2021 at 07:24PM. Read full article at Stem Cells in the News Portal .

TreeFrog Therapeutics has raised $75 million in financing to support the clinical development of its stem cell-derived cell therapies for Parkinson’s disease, the company said in a press release.The new financing round, which brings the total funding to date to $83 million, will allow the company to use its C-Stem technology to expand the growth of [...] Published September 17, 2021 at 11:55AM. Read full article at Stem Cells in the News Portal .

Credit: ShutterstockDoes amniotic tissue help knee arthritis pain? That’s been an open question for some time. Thankfully this question is beginning to get answered by FDA clinical trials, the earliest of which are now beginning to report results. One such report this week could spell trouble for the other half dozen companies involved in knee [...] Published September 17, 2021 at 03:32AM. Read full article at Stem Cells in the News Portal .

Stem cell therapy is one of the most well-known and high-profile forms of medical treatment. For decades, medical researchers have used stem cell therapy to treat a myriad of conditions. However, stem cell therapy is growing in popularity and accessibility. As a result, more and more people may wonder if stem cell therapy is right [...] Published September 16, 2021 at 10:26PM. Read full article at Stem Cells in the News Portal .

Credit: ShutterstockPRP for the treatment of knee osteoarthritis has more evidence to support it than knee replacements, but the old guard is having a tough time accepting this new reality. A recent study in an old guard orthopedic journal could change some minds. Let’s review.DefinitionsBefore I begin, we need to define some things:Corticosteroid injections – [...] Published September 16, 2021 at 07:44AM. Read full article at Stem Cells in the News Portal .

1.Rawla, P., Sunkara, T. & Gaduputi, V. Epidemiology of pancreatic cancer: global trends, etiology and risk factors. World J. Oncol. 10, 10–27 (2019).Article  Google Scholar  2.Jan, M. et al. Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Sci. Transl. Med. 4, 149ra118 (2012).Article  Google Scholar  3.Barker, N. et al. Crypt stem [...] Published September 15, 2021 at 11:15PM. Read full article at Stem Cells in the News Portal .

1.Zawadzka, M. et al. CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination. Cell Stem Cell 6, 578–590 (2010).CAS  Article  Google Scholar  2.Hill, R. A., Li, A. M. & Grutzendler, J. Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain. Nat. Neurosci. 21, 683–695 (2018).CAS  [...] Published September 15, 2021 at 09:12AM. Read full article at Stem Cells in the News Portal .

Marc Darrow MD,JD You go to the doctor with a complaint of severe shoulder pain. The pain is at the top and side of your shoulder. You tell your doctor that the pain is much worse when you do anything where you have to reach over your head. You tell your doctor that you also [...] Published September 14, 2021 at 10:59PM. Read full article at Stem Cells in the News Portal .

Credit: ShutterstockSeveral months ago, during one of our weekly Friday Facebook Live events, a patient asked a super interesting question. What did they ask? If the season of your bone marrow draw impacted the recovery of cells. Let’s dig in.BMA 101A Bone Marrow Concentrate (BMC) procedure contains your own stem and other cells and is [...] Published September 14, 2021 at 07:15AM. Read full article at Stem Cells in the News Portal .

The back consists of 33 vertebrae, small bones that are each separated by a disc-shaped cushion of fibrocartilage known as an intervertebral disc. Each disc has a gel-like center (the nucleus pulposus) surrounded by a tough, fibrous ring (the annulus fibrosus). Together, the vertebrae and discs work to protect the spinal cord and brain, support [...] Published September 13, 2021 at 08:07PM. Read full article at Stem Cells in the News Portal .

Hips are some of the strongest and largest joints in the body. They support the body’s weight and provide a wide range of motion. Despite their power, hips are susceptible to disease, trauma, and gradual degradation. Over time, hip joints can succumb to many different pathologies.  For example, osteoarthritis is one of the leading causes [...] Published September 13, 2021 at 08:55AM. Read full article at Stem Cells in the News Portal .

Credit: ShutterstockI write often enough that unless I’m passionate about what goes on the page, it’s hard to keep up. This is one of those blogs that will upset a significant number of my physician readers but because my “Irish is up”, it needs to make it to a blog. The topic is the explosion [...] Published September 12, 2021 at 12:43PM. Read full article at Stem Cells in the News Portal .

Stem cells may have anti-aging properties, but they are unlikely to be a real fountain of youth. Even so, people are obsessed with aging and stem cells regularly are thought of as “the ticket” for fighting aging. I’ll start today’s recommended reads with that topic and then go on to list some interesting papers of [...] Published September 12, 2021 at 07:30AM. Read full article at Stem Cells in the News Portal .

Study approvalThis study conforms to the Declaration of Helsinki and was approved by the Ethics Committee of the Eighth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. The experiments on mice were approved by the Institutional Animal Care and Use Committee of Sun Yat-Sen University, Guangzhou, China. All experimental procedures on mice were carried out in [...] Published September 10, 2021 at 11:23PM. Read full article at Stem Cells in the News Portal .

Marc Darrow MD,JD We will often see patients who have lingering elbow pain. They continue to receive and remedy themselves with traditional “conservative” treatments that include resting, icing, anti-inflammatory medications, Kinesio tape and various other health care provided treatments including physical therapy, massage, cortisone injections and even acupuncture. While some will respond to these treatments [...] Published September 10, 2021 at 06:33PM. Read full article at Stem Cells in the News Portal .

Credit: ShutterstockDoes the brain control the heart or is it the other way around? Does chronic fight or flight cause people to make bad decisions? This is a critical topic for patients with chronic pain. Let’s dig into some new research that upset what we thought we knew about how the brain works.TachycardiaTachycardia means rapid [...] Published September 10, 2021 at 08:19AM. Read full article at Stem Cells in the News Portal .