Stem Cells in the News

Screening possible immune functions related to anticancer treatmentCommon immune checkpoints were browsed and screened for possible immunotherapeutic value, and the representative immune checkpoint molecules13,14,15 ADORA2A, BTLA, Nectin-2 (CD112), CD160, CD244, PD-L1, CD96, CSF1R, CTLA4, HAVCR2, IDO1, IL10, IL10RB, KDR, KIR2DL1, KIR2DL3, LAG3, LGALS9, PDCD1, PDCD1LG2, PVRL2, TGFB1, TGFBR1, TIGIT, VTCN1, TNF Receptor Superfamily Member 14 [...] Published September 20, 2021 at 02:42PM. Read full article at Stem Cells in the News Portal .

Are prematurely aged or overworked stem cells a significant factor in chronic lung disease? Findings of a study just released in STEM CELLS Translational Medicine (SCTM) say this is likely so. The study determined that repeated injury to the epithelial tissue of the airways causes “biological aging” of the stem cells located there. “This premature aging of [...] Published September 21, 2021 at 08:15AM. Read full article at Stem Cells in the News Portal .

Dear Editor,Up to now, hematopoietic stem cells (HSCs) that contribute to all mature blood cell lineages in adults still cannot be efficiently regenerated in vitro, at least in part due to the insufficient understanding of their physiological developmental trajectories and the underlying precise regulatory mechanisms. In mouse embryos, the first HSCs are believed to be [...] Published September 20, 2021 at 09:39PM. Read full article at Stem Cells in the News Portal .

I’ve been busy recently focusing more on grant and paper writing than reading papers on stem cells, but my piece on trying to de-extinct mammoths via cloning-like methods drew strong opinions on both sides.Recent news and resources on stem cellsWe’re still awaiting a verdict in the big California federal court case where the FDA is seeking a [...] Published September 19, 2021 at 03:15PM. Read full article at Stem Cells in the News Portal .

Credit: ShutterstockLike a headline from the Onion, I recently read an email describing a big orthopedic surgery conference where a panel was sourced on whether or not you needed ultrasound guidance to inject a knee. While the result of this panel was a LOL moment for many of my colleagues, none of us really knew [...] Published September 18, 2021 at 02:55PM. Read full article at Stem Cells in the News Portal .

1.Chaffer, C. L. & Weinberg, R. A. A perspective on cancer cell metastasis. Science 331, 1559–1564 (2011).CAS  PubMed  Article  PubMed Central  Google Scholar  2.Tseng, P.-L. et al. The decrease of glycolytic enzyme hexokinase 1 accelerates tumor malignancy via deregulating energy metabolism but sensitizes cancer cells to 2-deoxyglucose inhibition. Oncotarget 9, 18949–18969 (2018).PubMed  PubMed Central  Article  [...] Published September 17, 2021 at 07:24PM. Read full article at Stem Cells in the News Portal .

TreeFrog Therapeutics has raised $75 million in financing to support the clinical development of its stem cell-derived cell therapies for Parkinson’s disease, the company said in a press release.The new financing round, which brings the total funding to date to $83 million, will allow the company to use its C-Stem technology to expand the growth of [...] Published September 17, 2021 at 11:55AM. Read full article at Stem Cells in the News Portal .

Newswise — Researchers from the group of Hans Clevers in collaboration with the group of Bart Haagmans (Erasmus MC) established an organoid biobank to search for the genes that are essential for the spreading of a SARS-CoV2 infection. Their study was published in Nature Communications on 17 September and highlights the usefulness of organoids for [...] Published September 17, 2021 at 02:56PM. Read full article at Stem Cells in the News Portal .

Credit: ShutterstockDoes amniotic tissue help knee arthritis pain? That’s been an open question for some time. Thankfully this question is beginning to get answered by FDA clinical trials, the earliest of which are now beginning to report results. One such report this week could spell trouble for the other half dozen companies involved in knee [...] Published September 17, 2021 at 03:32AM. Read full article at Stem Cells in the News Portal .

Stem cell therapy is one of the most well-known and high-profile forms of medical treatment. For decades, medical researchers have used stem cell therapy to treat a myriad of conditions. However, stem cell therapy is growing in popularity and accessibility. As a result, more and more people may wonder if stem cell therapy is right [...] Published September 16, 2021 at 10:26PM. Read full article at Stem Cells in the News Portal .

Bone injuries in the face and skull -- known as craniomaxillofacial defects -- can be caused by sports injuries, vehicle accidents, or battlefield injuries. Repairing such defects is complicated because different types of cells need to interact with each other. In a new study, researchers are investigating the types of material used in reconstruction to [...] Published September 13, 2021 at 09:44PM. Read full article at Stem Cells in the News Portal .

Newswise — ITHACA, N.Y. -- A new Cornell study has found the antimicrobial properties of certain stem cell proteins could offer a potential treatment to reduce infection in skin wounds.Treating wounds with the secretion of a type of stem cell effectively reduced the viability of methicillin-resistant Staphylococcus aureus – better known as MRSA – according to [...] Published September 16, 2021 at 12:36PM. Read full article at Stem Cells in the News Portal .

Credit: ShutterstockPRP for the treatment of knee osteoarthritis has more evidence to support it than knee replacements, but the old guard is having a tough time accepting this new reality. A recent study in an old guard orthopedic journal could change some minds. Let’s review.DefinitionsBefore I begin, we need to define some things:Corticosteroid injections – [...] Published September 16, 2021 at 07:44AM. Read full article at Stem Cells in the News Portal .

A study released in STEM CELLS Translational Medicine (SCTM), by researchers at the Baker Institute for Animal Health, part of Cornell University’s College of Veterinary Medicine, Ithaca, N.Y., details in a relevant ex vivo model how treating wounds with the secretion of a type of stem cell called mesenchymal stromal cell (MSC) effectively reduced methicillin-resistant Staphylococcus aureus – better known [...] Published September 16, 2021 at 08:35AM. Read full article at Stem Cells in the News Portal .

1.Rawla, P., Sunkara, T. & Gaduputi, V. Epidemiology of pancreatic cancer: global trends, etiology and risk factors. World J. Oncol. 10, 10–27 (2019).Article  Google Scholar  2.Jan, M. et al. Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Sci. Transl. Med. 4, 149ra118 (2012).Article  Google Scholar  3.Barker, N. et al. Crypt stem [...] Published September 15, 2021 at 11:15PM. Read full article at Stem Cells in the News Portal .

As we age, our bones become thinner, we suffer fractures more often, and bone-diseases such as osteoporosis are more likely to occur. One responsible mechanism involves the impaired function of the bone-marrow stem cells, which are required for the maintenance of bone integrity. Researchers from the Max Planck Institute for Biology of Ageing and CECAD [...] Published September 14, 2021 at 12:37PM. Read full article at Stem Cells in the News Portal .

Newswise — A textile-based implant containing cartilage derived from stem cells reduced pain and restored hip joint function to baseline levels in a study of dogs with symptoms of moderate osteoarthritis. The study, led by researchers at North Carolina State University, Washington University in St. Louis and Cytex Therapeutics Inc., could be a significant first [...] Published September 15, 2021 at 04:04PM. Read full article at Stem Cells in the News Portal .

A University at Buffalo-led research team has shown that a protein named for the mythical land of youth in Irish folklore is effective at reversing aging in skeletal muscle cells. Published Sept. 3 in Science Advances, the study centers on the protein NANOG, which is derived from Tír na nÓg, a place in Irish lore [...] Published September 14, 2021 at 06:13PM. Read full article at Stem Cells in the News Portal .

An immunological molecule called fractalkine can boost the production of brain cells that produce myelin, a key factor in diseases such as multiple sclerosis, according to recent research from the University of Alberta. Myelin is an insulating layer around nerves that is gradually worn away by inflammation in multiple sclerosis and similar diseases. Without this [...] Published September 09, 2021 at 01:26PM. Read full article at Stem Cells in the News Portal .

1.Zawadzka, M. et al. CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination. Cell Stem Cell 6, 578–590 (2010).CAS  Article  Google Scholar  2.Hill, R. A., Li, A. M. & Grutzendler, J. Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain. Nat. Neurosci. 21, 683–695 (2018).CAS  [...] Published September 15, 2021 at 09:12AM. Read full article at Stem Cells in the News Portal .