Stem Cells in the News

Are prematurely aged or overworked stem cells a significant factor in chronic lung disease? Findings of a study just released in STEM CELLS Translational Medicine (SCTM) say this is likely so. The study determined that repeated injury to the epithelial tissue of the airways causes “biological aging” of the stem cells located there. “This premature aging of [...] Published September 21, 2021 at 08:15AM. Read full article at Stem Cells in the News Portal .

A study released in STEM CELLS Translational Medicine (SCTM), by researchers at the Baker Institute for Animal Health, part of Cornell University’s College of Veterinary Medicine, Ithaca, N.Y., details in a relevant ex vivo model how treating wounds with the secretion of a type of stem cell called mesenchymal stromal cell (MSC) effectively reduced methicillin-resistant Staphylococcus aureus – better known [...] Published September 16, 2021 at 08:35AM. Read full article at Stem Cells in the News Portal .

Mouse embryonic stem cells undergoing electrochemical specialization, labeled for nuclei (blue) and neuron projections (red). Credit: © Mitchell Foster and Adele Doyle New TU Dresden research group aims to uncover how stem cells respond to mechanical forces and electrical cues during the development and maintenance of the nervous and cardiovascular system. Dr. Adele Doyle, Assistant [...] Published September 12, 2021 at 06:09AM. Read full article at Stem Cells in the News Portal .

Illinois researchers developed a method that makes membrane-bound receptors reactive to light, triggering the Wnt pathway, important in embryonic development and cancer. Credit: Image courtesy of Kai Zhang Blue light is illuminating new understanding of a key signaling pathway in embryo development, tissue maintenance, and cancer genesis. Researchers at the University of Illinois Urbana-Champaign developed [...] Published September 08, 2021 at 12:02PM. Read full article at Stem Cells in the News Portal .

A convection-enhanced encapsulation device as pictured enhances nutrient transport leading to improved survival and improved glucose responsive insulin secretion of the transplanted beta cells. Credit: Randal McKenzie Brigham bioengineers have developed a convection-enhanced macroencapsulation device that offers the potential of faster and more effective treatment for people with type 1 diabetes. More than 40 million [...] Published September 06, 2021 at 02:38PM. Read full article at Stem Cells in the News Portal .

Basal epithelial stem cells (green) containing the protein IL-33 (red) are visible in a sample of lung tissue (pictured). Researchers at Washington University School of Medicine in St. Louis have found that such stem cells multiply during and after a viral respiratory infection, sometimes triggering a detrimental remodeling process that can cause persistent lung disease [...] Published August 28, 2021 at 10:50AM. Read full article at Stem Cells in the News Portal .

This image shows a brain organoid with optic cups. Credit: Elke Gabriel Human induced pluripotent stem cells (iPSCs) can be used to generate brain organoids containing an eye structure called the optic cup, according to a study published on August 17, 2021, in the journal Cell Stem Cell. The organoids spontaneously developed bilaterally symmetric optic [...] Published August 19, 2021 at 10:51AM. Read full article at Stem Cells in the News Portal .

Human stem cells in a glass needle are being injected into a mouse embryo held by the pipette on the left. Credit: Image by Aimee Stablewski and Dawn Barnas at the Gene Targeting and Transgenic Resource, Roswell Park Comprehensive Cancer Center The research enables far more accurate models of human development and disease and could [...] Published August 18, 2021 at 08:49AM. Read full article at Stem Cells in the News Portal .

A section of liver tissue, showing mesenchymal cells (in pink) contacting and wrapping around the liver ductal cells (also known as cholangiocytes, in yellow and blue) during the final stages of ductal-driven liver regeneration. All cell nuclei are visible in blue. Mesenchymal cells, with long cell protrusions, reminded the paper authors of octopuses. Credit: Anna [...] Published August 18, 2021 at 01:15AM. Read full article at Stem Cells in the News Portal .

Inflamed mouse stem cells located in the basal layer (red) of the epidermis and FOS (green), a near-universal stress response factor essential to inflammatory memory. Credit: Christopher Cowley When a tissue experiences inflammation, its cells remember. Pinning proteins to its genetic material at the height of inflammation, the cells bookmark where they left off in [...] Published August 04, 2021 at 11:59PM. Read full article at Stem Cells in the News Portal .

A study released in STEM CELLS Translational Medicine has confirmed the safety of a novel type of cellular therapy for knee pain caused by osteoarthritis. Conducted by a multi-institutional team of researchers in Japan who had developed the new therapy, the study was designed to confirm that their treatment – which involves transplanting the patient’s own mesenchymal [...] Published August 03, 2021 at 08:35AM. Read full article at Stem Cells in the News Portal .

The organ of Corti, the hearing organ of the inner ear, contains rows of sensory hearing cells (green) surrounded by supporting cells (blue). Credit: Image by Yassan Abdolazimi/Segil Lab/USC Stem Cell Scientists from the <span aria-describedby="tt" class="glossaryLink" data-cmtooltip="USCFounded in 1880, the University of Southern California is one of the world's leading private research universities. It [...] Published July 30, 2021 at 10:28AM. Read full article at Stem Cells in the News Portal .

Results of a compassionate-use study released in STEM CELLS Translational Medicine show promising results for treating muscular dystrophies with mesenchymal stem cells (MSCs) derived from Wharton’s jelly (WJ), a substance found in the umbilical cord. Led by doctors at Klara Medical Center (KMC), Czestochowa, Poland, these WJ-MSC treatments resulted in significant improvement in several body muscles in [...] Published July 27, 2021 at 08:11AM. Read full article at Stem Cells in the News Portal .

Novel kidney organoid recapitulating the patterned distribution of principal cells (red) and intercalated cells (green) of an adult kidney’s collecting duct system. Credit: Zipeng Zeng/Li Lab The organoids, which resemble a kidney’s uretic buds, provide a way to study kidney disease that could lead to new treatments and regenerative approaches for patients. A team of [...] Published June 19, 2021 at 05:17AM. Read full article at Stem Cells in the News Portal .

Critically ill COVID-19 patients treated with non-altered stem cells from umbilical cord connective tissue were more than twice as likely to survive as those who did not have the treatment, according to a study published today (June 8, 2021) in STEM CELLS Translational Medicine. The clinical trial, carried out at four hospitals in Jakarta, Indonesia, [...] Published June 08, 2021 at 08:11AM. Read full article at Stem Cells in the News Portal .

Bone marrow failure due to acute myeloid leukemia (AML) is a significant factor behind the disease’s high rate of morbidity and mortality. Previous studies in mice suggest that AML cells inhibit healthy hematopoietic (blood) stem and progenitor cells (HSPC). A study released in STEM CELLS adds to this extent of knowledge by showing how secreted cell factors, [...] Published May 20, 2021 at 08:09AM. Read full article at Stem Cells in the News Portal .

Left is stem cell embryo model; right is nature human embryo. Credit: University of Exeter Exeter scientists have discovered a simple, efficient way to recreate the early structure of the human embryo from stem cells in the laboratory. The new approach unlocks new ways of studying human fertility and reproduction. Stem cells have the ability [...] Published May 07, 2021 at 08:20AM. Read full article at Stem Cells in the News Portal .

The cancer stem cells cultured on the DN gel formed a tumor when injected into mice brain. Credit: Jun Suzuka et al., Nature Biomedical Engineering, March 29, 2021 A hydrogel, a type of soft matter, developed at Hokkaido University successfully reverted cancer cells back to cancer stem cells within 24 hours, in six different human [...] Published March 29, 2021 at 10:12AM. Read full article at Stem Cells in the News Portal .

Illustration of fat cells. Nuclear power offers an efficient, reliable way to provide energy to large populations — as long as all goes well. Accidents involving nuclear reactors such as those that took place in 1986 at Chernobyl and at Fukushima Daiichi after the March 2011 tsunami raise major concerns about what happens if the [...] Published March 16, 2021 at 08:27AM. Read full article at Stem Cells in the News Portal .

The smart stem cells, made from human fat, adapt to their surroundings to repair damaged tissue. These new, adaptive stem cells can lie dormant until needed, a new animal study using human cells shows. A new type of stem cell – that is, a cell with regenerative abilities – could be closer on the horizon, [...] Published February 02, 2021 at 03:11PM. Read full article at Stem Cells in the News Portal .