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Showing posts with the label Diabetes

Oncostatin M regulates hematopoietic stem cell (HSC) niches in the bone marrow to restrict HSC mobilization

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1.Crane GM, Jeffery E, Morrison SJ. Adult haematopoietic stem cell niches. Nat Rev Immunol. 2017;17:573–90.CAS  PubMed  Article  PubMed Central  Google Scholar  2.Spencer JA, Ferraro F, Roussakis E, Klein A, Wu J, Runnels JM, et al. Direct measurement of local oxygen concentration in the bone marrow of live animals. Nature. 2014;508:269–73.CAS  PubMed  PubMed Central  Article  Google [...] Published September 12, 2021 at 07:25PM. Read full article at Stem Cells in the News Portal .

Further validation of the efficacy of mesenchymal stem cell infusions for reducing mortality in COVID-19 patients with ARDS

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1.Munster, V. J., Koopmans, M., van Doremalen, N., van Riel, D. & de Wit, E. A novel coronavirus emerging in China - key questions for impact assessment. N. Engl. J. Med. 382, 692–694 (2020).CAS  Article  Google Scholar  2.Zhou, P. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579, [...] Published September 09, 2021 at 07:56AM. Read full article at Stem Cells in the News Portal .

Ep. 201: “The Future of Research” Featuring Drs. Bria Macklin, Matthew Sinton, and Leili Rohani

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Podcast: Play in new window | Download | EmbedSubscribe: Guests: In this special episode of the Stem Cell Podcast, we speak with three postdocs from different parts of the world about their research in and outside of the lab. Dr. Bria Macklin is a Postdoc at the Gladstone Institutes. Her PhD research at Johns Hopkins [...] Published September 07, 2021 at 06:49PM. Read full article at Stem Cells in the News Portal .

Building a Better Bioartificial Pancreas for More Effective Treatment for People With Type 1 Diabetes

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A convection-enhanced encapsulation device as pictured enhances nutrient transport leading to improved survival and improved glucose responsive insulin secretion of the transplanted beta cells. Credit: Randal McKenzie Brigham bioengineers have developed a convection-enhanced macroencapsulation device that offers the potential of faster and more effective treatment for people with type 1 diabetes. More than 40 million [...] Published September 06, 2021 at 02:38PM. Read full article at Stem Cells in the News Portal .

Researchers use stem cells to make insulin-producing pancreatic beta cells

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The human body can be genetically inclined to attack its own cells, destroying the beta cells in the pancreas that make insulin, which helps convert sugar into energy. Called Type 1 diabetes, this disorder can occur at any age and can be fatal if not carefully managed with insulin shots or an insulin pump to [...] Published August 29, 2021 at 08:00PM. Read full article at Stem Cells in the News Portal .

Researchers use stem cells to make insulin-producing pancreatic beta cells

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The human body can be genetically inclined to attack its own cells, destroying the beta cells in the pancreas that make insulin, which helps convert sugar into energy. Called Type 1 diabetes, this disorder can occur at any age and can be fatal if not carefully managed with insulin shots or an insulin pump to [...] Published August 26, 2021 at 04:29PM. Read full article at Stem Cells in the News Portal .

What Is Bioxcellerator?

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Credit: ShutterstockThis is one that has been on my radar for a few years, but I’m just now getting around to covering it. What is Bioxcellerator? What does it have to do with legitimate scientists? Is this place for real or not? Is there any data that this treatment works? The truth here is a [...] Published August 25, 2021 at 06:47PM. Read full article at Stem Cells in the News Portal .

Cell Encapsulation Biotech Raises €7M to Target Cell Therapy Bottlenecks

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The French company Treefrog Therapeutics has raised over €7M in Series A investment to develop its encapsulation technology to improve the production of stem cells for cell therapies. Part of the Series A money will help Treefrog to automate its stem cell production process by 2021. The round will also fund the development of a [...] Published August 14, 2021 at 01:42PM. Read full article at Stem Cells in the News Portal .

How Quickly Do You Resolve Inflammation?

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Credit: ShutterstockInflammation is a complex subject. On the one hand, it’s how we heal and on the other hand, it’s increasingly how many of us die. So today we’ll explore the concept of resolving inflammation after a procedure and what that tells us about overall health and metabolic problems. Let’s dig in.What is Inflammation?When we [...] Published August 07, 2021 at 02:14PM. Read full article at Stem Cells in the News Portal .

Stem Cells 101: Classification of Stem Cells according to their potency

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.fb-comments,.fb-comments span,.fb-comments span iframe[style]{min-width:100%!important;width:100%!important}The human body contains many different cells, which carry out specific functions. These are called differentiated cells. In contrast, a stem cell is undifferentiated. It gives rise to multiple cell types including more stem cells. A stem cell is formed when a sperm penetrates an egg. This is a special kind of [...] Published July 15, 2021 at 06:39AM. Read full article at Stem Cells in the News Portal .

Stem cells “reprogrammed” by diabetes could increase heart attack risk

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Diabetes has a long list of run-on health effects, and one of them is an increased risk of cardiovascular disease. Now, scientists at Oxford have uncovered a mechanism behind that, finding high blood sugar levels “reprogram” stem cells so the white blood cells they produce become inflammatory, creating more plaques that build up in blood [...] Published July 14, 2021 at 10:41PM. Read full article at Stem Cells in the News Portal .

Promises and pitfalls of beta cell–replacement therapies

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1.Gregory, J. M., Cherrington, A. D. & Moore, D. J. Diabetes 69, 837–847 (2020).CAS  Article  Google Scholar  2.Heller, S. Diabetes Res. Clin. Pract. 65 (Suppl. 1), S23–S27 (2004).3.Warnock, G. L. et al. Transplantation 86, 1762–1766 (2008).Article  Google Scholar  4.Gamble, A., Pepper, A. R., Bruni, A. & Shapiro, A. M. J. Islets 10, 80–94 (2018).Article  Google [...] Published July 11, 2021 at 08:00PM. Read full article at Stem Cells in the News Portal .

Mediterranean Diet Tied to 30 Percent Reduced Diabetes Risk in Women

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What we eat affects our health either positively or negatively. Researchers have found reasonable evidence to suggest that the Mediterranean Diet, which is rich in fats, fruits, and vegetables, can help lower the rate of type 2 diabetes. A typical Mediterranean Diet is cooked with olive oil, lots of fish, and a limited number of [...] Published June 30, 2021 at 11:23PM. Read full article at Stem Cells in the News Portal .

Development of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase D signaling

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1.Bajaj, J., Diaz, E. & Reya, T. Stem cells in cancer initiation and progression. J Cell Biol. https://doi.org/10.1083/jcb.201911053 (2020).2.Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J. & Clarke, M. F. Prospective identification of tumorigenic breast cancer cells. Proc. Natl Acad. Sci. USA 100, 3983–3988 (2003).CAS  PubMed  PubMed Central  Article  Google Scholar  3.Driessens, G., [...] Published June 23, 2021 at 07:05PM. Read full article at Stem Cells in the News Portal .

Stem cell therapy for diabetes updates: expected IPO, CRISPR, new pubs, more

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The idea of stem cell therapy for diabetes is both exciting and in a way practical. By that I mean that there’s a good common sense foundation here.“Comparison and advancement of subcutaneous insulin delivery, islet cell transplant, and novel inducible pluripotent stem cell-based islet cell transplant for cure of diabetes” Screenshot of Fig. 4 Verhoeff, [...] Published June 22, 2021 at 03:34PM. Read full article at Stem Cells in the News Portal .

Stem Cells & The Fight Against Chronic Liver Disease

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Over the past two decades, the field of regenerative medicine has made incredible advancements due to the findings of stem cell research as a therapeutic agent. Stem cells, either from cultured cells or isolated from tissues of the patient such as fat or bone marrow, have been used to treat a wide range of diseases [...] Published June 22, 2021 at 06:55AM. Read full article at Stem Cells in the News Portal .

Scientists Make Big Progress in Building Mini-Kidneys – “Essential Milestone Towards Building a Functional Organ”

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Novel kidney organoid recapitulating the patterned distribution of principal cells (red) and intercalated cells (green) of an adult kidney’s collecting duct system. Credit: Zipeng Zeng/Li Lab The organoids, which resemble a kidney’s uretic buds, provide a way to study kidney disease that could lead to new treatments and regenerative approaches for patients. A team of [...] Published June 19, 2021 at 05:17AM. Read full article at Stem Cells in the News Portal .

Immune modulation via adipose derived Mesenchymal Stem cells is driven by donor sex in vitro

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1.Mafi, R., Hindocha, S., Mafi, P., Griffin, M. & Khan, W. S. Sources of adult mesenchymal stem cells applicable for musculoskeletal applications - a systematic review of the literature. Open Orthop. J. 5(Suppl 2), 242–248. https://doi.org/10.2174/1874325001105010242 (2011).Article  PubMed  PubMed Central  Google Scholar  2.Wagner, W. et al. Comparative characteristics of mesenchymal stem cells from human bone [...] Published June 13, 2021 at 07:25PM. Read full article at Stem Cells in the News Portal .

Emerging understanding of apoptosis in mediating mesenchymal stem cell therapy

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1.McCulloch, E. A. & Till, J. E. The radiation sensitivity of normal mouse bone marrow cells, determined by quantitative marrow transplantation into irradiated mice. Radiat. Res. 13, 115–125 (1960).CAS  PubMed  Article  PubMed Central  Google Scholar  2.Friedenstein, A. J., Chailakhjan, R. K. & Lalykina, K. S. The development of fibroblast colonies in monolayer cultures of guinea-pig [...] Published June 08, 2021 at 07:48PM. Read full article at Stem Cells in the News Portal .

Survival of Critically Ill COVID-19 Patients Doubled by Birth Cord Stem Cell Treatment

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Critically ill COVID-19 patients treated with non-altered stem cells from umbilical cord connective tissue were more than twice as likely to survive as those who did not have the treatment, according to a study published today (June 8, 2021) in STEM CELLS Translational Medicine. The clinical trial, carried out at four hospitals in Jakarta, Indonesia, [...] Published June 08, 2021 at 08:11AM. Read full article at Stem Cells in the News Portal .