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The immunotherapy candidate TNFSF4 may help the induction of a promising immunological response in breast carcinomas

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Screening possible immune functions related to anticancer treatmentCommon immune checkpoints were browsed and screened for possible immunotherapeutic value, and the representative immune checkpoint molecules13,14,15 ADORA2A, BTLA, Nectin-2 (CD112), CD160, CD244, PD-L1, CD96, CSF1R, CTLA4, HAVCR2, IDO1, IL10, IL10RB, KDR, KIR2DL1, KIR2DL3, LAG3, LGALS9, PDCD1, PDCD1LG2, PVRL2, TGFB1, TGFBR1, TIGIT, VTCN1, TNF Receptor Superfamily Member 14 [...] Published September 20, 2021 at 02:42PM. Read full article at Stem Cells in the News Portal .
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Prematurely Aged or Overworked Stem Cells Could Be Major Factor in Chronic Lung Disease

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Are prematurely aged or overworked stem cells a significant factor in chronic lung disease? Findings of a study just released in STEM CELLS Translational Medicine (SCTM) say this is likely so. The study determined that repeated injury to the epithelial tissue of the airways causes “biological aging” of the stem cells located there. “This premature aging of [...] Published September 21, 2021 at 08:15AM. Read full article at Stem Cells in the News Portal .
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The comprehensive DNA methylation landscape of hematopoietic stem cell development

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Dear Editor,Up to now, hematopoietic stem cells (HSCs) that contribute to all mature blood cell lineages in adults still cannot be efficiently regenerated in vitro, at least in part due to the insufficient understanding of their physiological developmental trajectories and the underlying precise regulatory mechanisms. In mouse embryos, the first HSCs are believed to be [...] Published September 20, 2021 at 09:39PM. Read full article at Stem Cells in the News Portal .
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Weekly reads: news, legos for stem cells, FDA, cancer, more

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I’ve been busy recently focusing more on grant and paper writing than reading papers on stem cells, but my piece on trying to de-extinct mammoths via cloning-like methods drew strong opinions on both sides.Recent news and resources on stem cellsWe’re still awaiting a verdict in the big California federal court case where the FDA is seeking a [...] Published September 19, 2021 at 03:15PM. Read full article at Stem Cells in the News Portal .
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Is Injecting a Knee Blind Associated with Worse Health Outcomes?

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Credit: ShutterstockLike a headline from the Onion, I recently read an email describing a big orthopedic surgery conference where a panel was sourced on whether or not you needed ultrasound guidance to inject a knee. While the result of this panel was a LOL moment for many of my colleagues, none of us really knew [...] Published September 18, 2021 at 02:55PM. Read full article at Stem Cells in the News Portal .
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Argininosuccinate lyase is a metabolic vulnerability in breast development and cancer

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1.Chaffer, C. L. & Weinberg, R. A. A perspective on cancer cell metastasis. Science 331, 1559–1564 (2011).CAS  PubMed  Article  PubMed Central  Google Scholar  2.Tseng, P.-L. et al. The decrease of glycolytic enzyme hexokinase 1 accelerates tumor malignancy via deregulating energy metabolism but sensitizes cancer cells to 2-deoxyglucose inhibition. Oncotarget 9, 18949–18969 (2018).PubMed  PubMed Central  Article  [...] Published September 17, 2021 at 07:24PM. Read full article at Stem Cells in the News Portal .
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$75M Funding Will Help TreeFrog Develop Stem Cell Therapies

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TreeFrog Therapeutics has raised $75 million in financing to support the clinical development of its stem cell-derived cell therapies for Parkinson’s disease, the company said in a press release.The new financing round, which brings the total funding to date to $83 million, will allow the company to use its C-Stem technology to expand the growth of [...] Published September 17, 2021 at 11:55AM. Read full article at Stem Cells in the News Portal .
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